Gene activity in the brain depends on genetic background: Implications for individual differences in drug safety and efficacy
ScienceDaily (2010-10-19) — Researchers have found that the same genes have different activity patterns in the brain in individuals with different genetic backgrounds.
Re-emphasizing the importance of genetic background in mouse animal models of neurological diseases!
These findings may help to explain individual differences in the effectiveness and side-effect profiles of therapeutic drugs and thus have implications for personalized medicine.
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